20-Week Study of Clinical Outcomes of Over-the-Counter COVID-19 Prophylaxis and Treatment, by Leon Margolin, MD, PhD, Jeremy Luchins, PhD, Daniel Margolin, Bsc, Michelle Margolin, and Sanford Lefkowitz, MSc

The study indicates that a number of things you can get over the counter help to prevent Covid-19. From Leon Margolin, MD, PhD, Jeremy Luchins, PhD, Daniel Margolin, Bsc,

Michelle Margolin, and Sanford Lefkowitz from journals the Journal of Evidence-Based Integrative Medicine at journals.sagepub.com:

As the lethal COVID-19 pandemic enters its second year, the need for effective modalities of alleviation remains urgent. This includes modalities that can readily be used by the public to reduce disease spread and severity. Such preventive measures and early-stage treatments may temper the immediacy of demand for advanced anti-COVID measures (drugs, antibodies, vaccines) and help relieve strain also on other health system resources.

We present results of a clinical study with a multi-component OTC “core formulation” regimen used in a multiply exposed adult population. Analysis of clinical outcome data from our sample of over 100 subjects − comprised of roughly equal sized regimen-compliant (test) and non-compliant (control) groups meeting equivalent inclusion criteria − demonstrates a strong statistical significance in favor of use of the core formulations.

While both groups were moderate in size, the difference between them in outcomes over the 20-week study period was large and stark: Just under 4% of the compliant test group presented flu-like symptoms, but none of the test group was COVID-positive; whereas 20% of the non-compliant control group presented flu-like symptoms, three-quarters of whom (15% overall of the control group) were COVID-positive.

Offering a low cost, readily implemented anti-viral approach, the study regimen may serve, at the least, as a stopgap modality and, perhaps, as a useful tool in combatting the pandemic.

There is a pressing need for formulations and methods for COVID-19 alleviation that can be easily accessed and utilized by the public. That the alleviation should encompass prophylaxis and early-stage treatment is underscored by studies confirming spread of COVID-19 by asymptomatic/pre-symptomatic carriers1,2; by widespread upsurges of new confirmed COVID-19 cases amid second-wave concerns3; and by identification of ongoing mutations of the COVID-19-causing SARS-CoV-2 coronavirus with diverse infectivity rates.46

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