Why are the current Covid-19 mass vaccinations to be considered a public health experiment, by Geert Vanden Bossche

Read this one carefully because the implications are quite disturbing. From Geert Vanden Bossche at geertvandenbossche.org:

Why are the current Covid-19 mass vaccinations to be considered a public health experiment of international concern?

First, there is no precedent to the use of non-replicating viral vaccines in mass vaccination campaigns conducted during a pandemic, or even epidemic, of a highly mutable virus. The challenge of such an undertaking becomes even more difficult as more infectious antigenic variants had already been circulating by the time the first mass vaccination campaigns were initiated (i.e., Alpha, Beta, and Gamma variants). Their spread was featured by distinct temporal and geographic patterns, the underlying mechanism of which was not understood. Prior to the start of this universal vaccination program no single publication existed that came even close to suggesting that mass vaccinations using vaccines that permit transmission could be successful in extinguishing a pandemic of a highly mutable virus. No such publication exists to this day, and the idea becomes even more preposterous when considering several infectious variants had already expanded in prevalence by the time the vaccines were rolled out. There is ample evidence from similarly highly mutable RNA viruses like Influenza virus and Enterovirus that expansion in prevalence of antigenic variants is driven by selective immune pressure on viral infectiousness exerted by antibodies, and that antigenic variation diminishes or even abolishes the protective neutralization capacity of Influenza virus or Enterovirus vaccines directed at a specific antigenic lineage (1, 2). Consequently, nonreplicating monovalent enteroviral vaccines, for example, are only used at scale in vaccination campaigns of vulnerable target groups (e.g., children) deployed to fight recurrent epidemics of life-threatening enterovirus infection (e.g., EV-A71) in the Asia Pacific region (3). Interestingly, the US FDA did not approve these vaccines due to ‘concerns about the effectiveness against different pandemic strains, safety, and quality control of vaccine production’ (3).

Mass vaccination programs previously conducted to combat viral epidemics/pandemics (e.g., smallpox, polio, measles, yellow fever) have nothing in common with the ongoing mass vaccination campaigns today as those viruses are very different in terms of their pathogenesis, transmissibility, route of infection, potential reservoirs, predominant effector mechanisms involved in antiviral immunity, susceptibility of population segments, as well as with regard to the vaccines used (all prior vaccination campaigns involved live-attenuated virus).

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